AML with t(16;16) or inv(16):

Typical immunophenotype for acute myeloid leukemia with t(16;16)(p13.1;q22) or inv(16)(p13.1q22); CBFB-MYH11 (see figures):

  • Often myelomonocytic
  • Myeloid blasts often CD34+, CD117+, CD13+ (most cases with homogenous bright expression), CD33+ (heterogenous), HLA-DR+

Presence of eosinophils with purple-violet granules larger than normal ones are typical morphologic findings.

Case 1:

t1616_1 t1616_2 t1616_3 t1616_4

Case 2:

t1616_5 t1616_6 t1616_7 t1616_8 t1616_9

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