AML with t(8;21):

Typical immunophenotype for acute myeloid leukemia with t(8;21)(q22;q22); RUNX1-RUNX1T1 (see figures; blasts in red):

  • Often show variable CD19 expression with subset positive for CyCD79a
  • Express CD34, CD117 (variable; often subset bright), HLA-DR (often bright), MPO
  • CD13+ (variable; some cases with weak expression; some with bright expression), CD33+ (often relatively weaker)

Can have partial CD7 and CD56 expression.

Aberrant expression of B-cell markers is not specific. The immunophenotype in conjunction with morphologic findings such as presence of thin Auer rods and myeloid dysplasia is suggestive of this entity.

t821_1 t821_2 t821_3 t821_4 t821_5 t821_6

Cells in green are normal B lymphocytes.


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