Monocytic maturation:

Maturing monocytes undergo sequential changes in the expression of key markers.

  • CD117 is progressively lost, but HLA-DR is maintained
  • CD64 is expressed at all stages of maturation
  • CD36 and CD11b, then CD14 and CD35 are progressively gained
  • CD300e/IREM2 is expressed at the mature monocyte stage
    • CD14 is normally expressed before IREM2
  • CD13 initially decreases when maturing toward promonocytes, before increasing at the mature monocyte stage (not shown here)
Monocytic maturation 1
Monocytic maturation 2
Monocytic maturation 3
Monocytic maturation 4
Monocytic maturation 5

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